HIEstem for IVH | 메디노

HIEstem Based on the disease mechanisms that are shared by HIE and IVH, HIEstem is now being developed for IVH. HIEstem is a second-generation cell therapeutics whose therapeutic effects are potentiated by Thrombin pre-conditioning (patent-technology of Medinno Inc.) Project code of HIEstem for IVH is MS2001.

PIPELINE

01. Primary Culture of Mesenchymal Stem Cells

from Wharton’s Jelly of Umbilical Cord

02. Drug Substrate (DS)

Wharton’s Jelly-derived Mesenchymal Stem Cells

03. Thrombin Pre-conditioning

Enhancing Therapeutic Effects of Wharton's Jelly-derived Mesenchymal Stem Cells

04. Drug Product (DP)

Thrombin pre-conditioned Wharton’s Jelly-derived Mesenchymal Stem Cells (HIEstem)

Non-clinical Data

In vivo Treatment Effect Volume of ventricle was significantly reduced by HIEstem In vivo Neuro-Protective Effect Apoptosis of neural cells (green) was reduced by HIEstem In vivo Immuno-Suppressive Effect Concentrations of inflammatory cytokines in the brain were reduced by HIEstem (#, P < 0.05) In vivo Functional Recovery Motor and Cognitive functions were improved by HIEstem

Development Stage

IND
Phase1
Phase2
BLA

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