ahNSC for SCI | 메디노

Spinal cord injury (SCI) induces permanent loss of sensory, motor, and autonomic functions below injury level. There is no effective therapy for SCI.

Adult Human Neural Stem Cell ahNSCs are derived from adult human brain and have therpeutic effects on spinal cord injury by differentiation into functional neural cells and secretion of neuroprotective, anti-gliosis, pro-angiogenic, and anti-inflrammatory paracrine factors. Project code of ahNSCs for SCI is MS2002.

PIPELINE

01. Isolation of Brain Clumps

from Adult Human Temporal Lobe

02. Adult Human Neural Stem Cells (ahNSCs)

Primary Culture of Brain Clumps

03. Drug Product (DP)

Adult Human Neural Stem Cells (ahNSCs)

Non-clinical Data

In vivo Functional Recovery Motor functions were improved by HIEstem, dose-dependently In vivo fate of transplanted adult human Neural Stem Cells Adult human neural stem cells differentiated into neurons, astrocytes and oligodentrocytes in vivo In vivo neuro-protective effect More host neurons survived by transplantation of adult human Neural Stem Cells In vivo neuro-protective effect More host neurons survived by transplantation of adult human Neural Stem Cells

Development Stage

IND
Phase1
Phase2
BLA

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